Comparative Genomics and Host Resistance against Infectious Diseases
نویسندگان
چکیده
منابع مشابه
Comparative genomics and host resistance against infectious diseases.
The large size and complexity of the human genome have limited the identification and functional characterization of components of the innate immune system that play a critical role in front-line defense against invading microorganisms. However, advances in genome analysis (including the development of comprehensive sets of informative genetic markers, improved physical mapping methods, and nov...
متن کاملHost Genomics in Infectious Diseases
Understanding mechanisms by which genetic variants predispose to complications of infectious diseases can lead to important benefits including the development of biomarkers to prioritize vaccination or prophylactic therapy. Family studies, candidate genes in animal models, and the absence of well-defined risks where the complications are rare all can point to genetic predisposition. The most co...
متن کاملHepcidin and Host Defense against Infectious Diseases
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli. While the role of hepcidin in iron regulation is well established, its contribution to host defense is emerging as complex and multifaceted. In this review, we summarize the literature on the role of hepcidin as a mediator of antimicrobia...
متن کاملMicrobial genomics and infectious diseases.
Copyright © 2011 Massachusetts Medical Society. The pace of technical advancement in microbial genomics has been breathtaking. Since 1995, when the first complete genome sequence of a free-living organism, Haemophilus inf luenzae, was published,1 1554 complete bacterial genome sequences (the majority of which are from pathogens) and 112 complete archaeal genome sequences have been determined, a...
متن کاملHost genes and infectious diseases.
This panel presented data on host genes that influence susceptibility to or manifestations of four infectious diseases: Puumala hantavirus infection, tuberculosis (TB), Lyme disease, and AIDS. Gus Birkhead, Council of State and Territorial Epidemiologists, introduced the session, highlighting its timeliness in relation to the rapidly emerging body of data on our 100,000 human genes that stems f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 1999
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid0501.990105